There's a company that builds upon decades-old research, which has developed a one-time probiotic treatment to change your mouth's microbiome to contain bacteria that don't attack your teeth (causing caries), but instead produce a weak antibiotic that disrupts the metabolism of the bacteria that do.

The new bacteria that live in your mouth also live from sugar, so the company's recommendation for jump-starting their reproduction after the treatment is to eat candy.

luminaprobiotic.com/science

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@raucao imho not worth it, unless it is a derivative of a traditional practice. Easier to just clean your mouth regularly

@vbhide How would pretty much certainly getting rid of caries for the rest of your life not be "worth it"?

@raucao because of the associated risks you pointed out for example the gut biome. You're introducing a genetically modified foreign species into your eco system. Default position is thats dangerous.

@vbhide That should be the default position, but if it can be proven safe in this case (and we're talking about bacteria, not gene therapy), then it could have tremendous benefits relative to the risks.

@vbhide ... especially because it's recently been shown just how dangerous cavities can be to the rest of the body, including the brain (e.g. significantly increasing the risk for dementia).

@raucao i have found a significant drop in tooth issues since i turned quasi carnivore. Not recommending that necessarily but the point is it would be better to attack root causes. There's a paper on this lemme see if i can find it. Then ofc there's weston price

@vbhide Even if you're extremely strict about cutting out sugar, it's almost impossible to guard your teeth long-term without significant manual cleaning and maintenance efforts. If I can get rid of the risk altogether, almost 100%, then no amount of strict lifestyle and nutrition choices (which you can't even make all the time when traveling) could beat that.

@vbhide We're talking about changing the mouth biome in a way that it literally takes any kind of sugar that would usually cause harm and turns it into more protection.

@raucao idk, from what i have seen of health there is never a 100%. It's always tradeoffs..

@vbhide I think I was pretty clear about it being a risk-benefit calculation. And yes, of course you can get close to 100% of your desired result (and I explicitly put a qualifier in front of that number in my reply) with many vaccines and other treatments.

@raucao @vbhide holy hell this sounds like a disaster waiting to happen. just stop eating sugar and practice better oral hygiene. "studies suggest" yea we have heard that before

@meowski @vbhide In fact, it seems like a disaster waiting to happen. Just stop cooking so much, don't stay up late when it's dark, and practice better candle and wood stove discipline!

@raucao @vbhide irrelevant, weak straw man arguments. there are plenty of serious concerns with GMOs and this is anything but a proven technology. it takes decades for long term risks of something like this to become apparent

i recommend you do it though, and keep eating candy. easy

@meowski @vbhide I don't eat candy at all, and have cut out refined sugar over a decade ago. You have no idea who I am, or what my health or teeth are like. Do yourself a favor and try not to make too many assumptions, just because I hinted at you being afraid of progress. It's natural to fear new technologies, and there's not much difference between electricity in 1889 and novel medical treatments in 2024 when it comes to irrational fear.

@raucao @vbhide i'm not "afraid" of your GMO bacteria. you're the one being reckless, ignoring the long term risks of introducing GMO strep into your mouth, not to mention the risks to others who aren't engaging in this treatment, since your GMO mouth bacteria will likely spread to others.

i simply know enough to not do stuff like this- because literally EVERY gmo so far has been an ecological disaster with unintended consequences.

bottom line, there's no free lunch. you want to take shortcuts, you're going to pay a price.

i like how they're setting up shop in honduras though. easier to get away with experimenting on 3rd world populations
@raucao @vbhide ps. mouth bacteria don't care whether it's refined sugar or something else like fruit sugar. dried fruit for example can definitely rot your teeth just like candy
@raucao @vbhide if you want to colonize yourself with GMO strep bacteria knock yourself out. hard pass here. i have zero dental problems because i don't eat a bunch of sugar and i actually take care of my teeth
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